To comprehensively assess the role of AHR signaling in the pathogenesis of AML, we analyzed RNA-Seq data from primary AML specimens treated with the AHR-modulating agent 6-bromoindirubin-3′oxime (BIO, an AHR agonist), sourced from the GEO datasets (GSE48843). This evidence concerns the gene AHR and acute myeloid leukemia.