IGHE and Increased total eosinophil count: Regarding the IL1RL1 gene located on chromosome 2q12, previous studies have suggested that the investigated SNPs (rs1420101, rs17026974, rs1921622) could potentially contribute to the promotion of type 2 inflammatory responses in the airways, characterized by increased eosinophilia, increased serum IgE levels, and decreased FEV1 reversibility.