It showed elevated total PrP levels in sporadic CJD (54 ± 25 ng/mL), followed by FTD (46 ± 27 ng/mL), AD (40 ± 29 ng/mL), VaD (37 ± 21 ng/mL), and LBD (33 ± 15 ng/mL), compared to healthy controls (22 ± 10 ng/mL) and the neurological disease control group (28 ± 34 ng/mL). Here, PRNP is linked to sporadic Creutzfeldt-Jakob disease.