Ferroptosis in DN may be regulated by key proteins and pathways, such as the tumor suppressor protein p53, which promotes ferroptosis by downregulating SLC7A11 (solute carrier family 7 member 11) and SLC3A2 (solute carrier family 3 member 2), components of system Xc− [121]. Here, SLC3A2 is linked to liver dysplastic nodule.