AKT1 and nasopharyngeal carcinoma: (2) Reduced CHL1 expression has been reported in neuroblastoma, and breast and nasopharyngeal cancers, where CHL1 expression has been linked to cell growth and inhibition of metastasis by suppressing the PI3K/AKT signaling pathway [77,78,79], while its overexpression significantly increases E-cadherin expression [80].