Demethylation or overexpression of HOXD10 has been shown to suppress proliferation and migration, and to promote apoptosis in CRC [106], which may be related to its ability to bind E-cadherin upstream sequences and positively regulate E-cadherin expression, as described in clear cell renal cell carcinoma [107]. The gene discussed is HOXD10; the disease is colorectal carcinoma.