These include fragile X-associated primary ovarian insufficiency (FXPOI), fragile X-associated tremor/ataxia syndrome (FXTAS), fragile X-associated neuropsychiatric disorders (FXAND), and a number of fragile X-associated conditions such as immune-mediated disorders, sleep apnea, hypertension, and migraine [1,2]. The gene discussed is PSMB5; the disease is fragile X-associated tremor/ataxia syndrome.