The frequency of FXTAS diagnosis was similar, as shown in the two bar plots of no APOε4 allele presentation; however, in individuals who had APOε4 allele, the FXTAS diagnosis was more confident (only possible, probable, and definite) in those individuals with KL-VS (KL-VShet+ + or KL-VShom+) compared to those without KL-VS (KL-VShet+ + or KLVS-hom+). This evidence concerns the gene KL and fragile X-associated tremor/ataxia syndrome.