TNF and psoriasis: Once activated, these cells promote the production of a barrage of proinflammatory mediators, including but not limited to TNF-α, IL-6, IL-1, IL-17, IL-22, IL-23, vascular endothelial growth factor (VEGF), and interferon (IFN)-γ from keratinocytes, lymphocytes, and other immune cells; additionally, these cells contribute to the immunopathogenesis of skin lesions and drive systemic involvement during the course of Psoriasis [59].