MTOR and neuroblastoma: Indeed, treatments of mouse neuroblastoma cells with individual metabolites that accumulate in HHcy, Hcy-thiolactone or N-Hcy-protein recapitulated changes in the Phf8 → H4K20me1 → mTOR → autophagy pathway and Aβ accumulation seen in Blmh-depleted or Met-supplemented HHcy wild-type mice [125].