Interestingly, Pon1 depletion induced changes in the Phf8 → H4K20me1 → mTOR → autophagy pathway in a Pon1−/−5xFAD mouse brain and in Pon1-silenced neuroblastoma cells that mimicked the changes induced by HHcy in a Pon1+/−5xFAD mouse brain and in Hcy-thiolactone- or N-Hcy-protein-treated mouse neuroblastoma N2a-APPswe cells [99]. Here, PHF8 is linked to neuroblastoma.