That PON1 plays an important role in the CNS is further supported by a recent study using a new mouse model of AD, the Pon1−/−5xFAD mouse, which elucidated molecular mechanism by which Pon1 maintains CNS homeostasis and protects the brain from the accumulation of Aβ, a hallmark of AD [99]. Here, PON1 is linked to Alzheimer disease.