A recent study found that the BPHL gene is overexpressed in lung cancer and promotes lung carcinogenesis and that the downregulation of the BPHL expression by RNA interference inhibited tumor growth and metastasis by impairing the progression of the cell cycle and inducing apoptosis in A549, NCI-H1975, and NCI-H-1299 human lung carcinoma cell lines [143]. The gene discussed is BPHL; the disease is lung cancer.