The study showed that Pon1 depletion, which causes the accumulation of Hcy-thiolactone and the N-Hcy-protein in mice [49], downregulated the histone demethylase Phf8 and upregulated the H4K20me1 epigenetic mark in brains of Pon1−/− mice and in Pon1-silenced mouse neuroblastoma N2a-APPswe cells [99]. The gene discussed is PON1; the disease is neuroblastoma.