Notably, silencing the Bphl gene by RNA interference in mouse neuroblastoma N2a-APPswe cells caused changes in the Phf8 → H4K20me1 → mTOR → autophagy pathway and APP/Aβ levels characteristic of AD [144], similar to the changes seen in mouse neuroblastoma N2a-APPswe cells in which Pon1 [99] or Blmh [125] was silenced by RNA interference. This evidence concerns the gene PHF8 and Alzheimer disease.