PHF8 and neuropathy: That Phf8 depletion could account for the neurological deficits in Blmh−/− and Blmh−/−5xFAD mice is supported by findings showing that PHF8 depletion in humans causes neurological impairments such as intellectual disability, autism spectrum disorder, and attention deficit hyperactivity disorder [128,129] and that Phf8−/− mice also show similar neuropathies [130].