In vitro, this combination was shown to induce iron-dependent reactive oxygen species (ROS) accumulation, glutathione (GSH) depletion, lipid peroxidation, up-regulation of HO-1 and transferrin, and down-regulation of negative regulatory proteins for ferroptosis (GPX4, SLC7A11, FTH1, glutaminase, and SLC40A1) in KRAS-mutant CRC cells. This evidence concerns the gene GLS and colorectal carcinoma.