The injection of IL-10-treated SVFs decreased inflammatory cytokines but increased CD4+ Tregs of SVFs and IL-10 levels in adipose tissue; suppressed insulin resistance, hepatic G6PC and PCK1 mRNA expression, plasma adiponectin levels, and DPP4 activity; and increased Akt and STAT3 phosphorylation in the livers of diabetic mice. This evidence concerns the gene CD4 and Insulin resistance.