To investigate whether the injection of IL-10-treated SVFs attenuates insulin resistance in diabetic mice, Leprdb/db mice were injected with PBS or IL-10-treated SVFs followed by insulin administration, and the protein expression of Akt phosphorylation, ERK phosphorylation, and STAT3 phosphorylation in the livers of Leprdb/db mice was measured. Here, STAT3 is linked to Insulin resistance.