Furthermore, a significant upregulation of soluble thrombomodulin (842.2 ± 379.4 ng/mL; p = 0.04) and receptor tyrosine kinase (Tie2; 744.6 ± 280.3 ng/mL; p = 0.014) expression was observed in comparison between HCs and T1DM individuals. Here, THBD is linked to type 1 diabetes mellitus.