TSLP and neoplasm: Specifically, we found that differentiation of Th2 cells was due to activation of myeloid dendritic cells (DCs) with Th2-polarizing capability that was dependent on the thymic stromal lymphopoietin (TSLP) secreted by tumor-derived IL-1-activated CAFs [20,21,22,23], pointing to a relevant indirect role for IL-1 in driving Th2-type inflammation in PDAC.