CAFs are a relevant cell population in the PDAC stroma that express IL-1R1 [51], and when stimulated with IL-1α and/or IL-1β, they secrete several pro-tumor cytokines [36,52,53], including TSLP, which is responsible for pro-tumor Th2 inflammation in PDAC [20,23]. This evidence concerns the gene IL1R1 and neoplasm.