Thus, WEE1 may be part of a signaling pathway, including FGF14 and Nav1.2, that, if perturbed, could contribute to endophenotypes related to neurodevelopmental disorders such as schizophrenia and SCN2A channelopathies associated with autism spectrum disorder and epilepsy [38,39,40,41,42,43,44,45,55,56,57,58,59,60,61]. Here, SCN2A is linked to channelopathy.