Increased expression of CXCL8 was detected in astrocytes situated in the marginal areas of active MS lesions, while on oligodendrocytes from MS patients upregulated expression of CXCL8 receptors CXCR(C-X-C motif chemokine receptor)1 and CXCR2 was observed [25]. This evidence concerns the gene CXCR2 and myeloid sarcoma.