While reporting no difference in concentrations of CXCL10 in sera of RRMS patients and controls, Sinder and co-workers observed decreased expression of its receptor, CXCR3, in peripheral blood T-cells from RRMS patients, and an increased concentration of CXCL10 in CSF during relapse [46]. The gene discussed is CXCL10; the disease is relapsing-remitting multiple sclerosis.