A recent study on PACAP and neuropathy in a streptozotocin-induced diabetes model [76] found that PACAP reduced morphological signs of nerve injury (axon–myelin separation, elevated mitochondrial number in myelinated axons, unmyelinated fiber atrophy, and basement membrane thickening of endoneurial vessels) while also attenuating pressure and touch hyperalgesia. The gene discussed is ADCYAP1; the disease is diabetes mellitus.