Overall, the results here are consistent with previous studies of the individual role of Nrf1 and Nrf2 on liver steatosis and steatohepatitis using embryonic null mice or transgenic promoter-driven Cre recombinase mice crossed with Nrf1 flox mice [15,16,17,18,19,21,22,23,25,26]. This evidence concerns the gene NFE2L2 and steatosis.