NFE2L2 and fatty liver disease: In control diet fed mice, Nrf2 deficiency was nonconsequential, while Nrf1 and combined deficiency exacerbated the effect, as demonstrated by hepatic steatosis as well as significant or trending increases in hepatic triglyceride and expression of Ccl2, Ccnb1, Col1a1, Col3a1, Ihh, and Tnfrsf12a (Figure S1A–C).