Our initial goal was to investigate the impact of hepatocyte deficiency for Nrf1 (Nfe2l1), Nrf2 (Nfe2l1), or both on the progression of diet-induced MASH, using Nfe2l1flox/flox mice, Nfe2l2flox/flox mice, and Nfe2l1flox/flox; Nfe2l2flox/flox mice, respectively, as described previously [20,24,27]. Here, NFE2L2 is linked to metabolic dysfunction-associated steatohepatitis.