NRF1 and hepatocellular carcinoma: But to our knowledge, our previous study has been the only one to systematically investigate the combined roles of hepatic Nrf1 and Nrf2 on stress defenses counteracting MASH [20], and this study is the only one to assess the combined roles of hepatic Nrf1 and Nrf2 on MASH-linked liver fibrosis and HCC.