NFE2L2 and metabolic dysfunction-associated steatohepatitis: High fat, fructose, and cholesterol (HFFC) diet-fed mice with a coinciding 1 to 3 weeks of hepatocyte deficiency for Nrf1 and Nrf2, but not either alone, exhibited severe MASH due to increased hepatic lipid storage, altered bile acid metabolism, and oxidative damage, whereas Nrf1 deficiency alone was sufficient to increase hepatic inflammation.