NRF1 and metabolic dysfunction-associated steatohepatitis: Here, we explored this possibility using a validated model of diet-induced MASH on transgenic mice amenable to adult-onset loss-of-function for hepatocyte Nrf1, Nrf2, or both and by enhancing the actions of Nrf1, Nrf2, or both in wild-type mice with MASH-linked fibrosis.