Similarly, Wang et al. showed that MiR-146b-5p inhibited the SMARCA5 subunit of ISWI in glioma stem-like cells/mesenchymal stem cell fusion cells, which led to an inactivation of a transforming growth factor-β (TGF-β) pathway and impaired proliferation and invasion of the fusion cell, thus suggesting a critical role in malignant progression [87]. The gene discussed is SMARCA5; the disease is central nervous system cancer.