For example, Xie et al. showed that circRNA vacuole membrane protein 1 (CircVMP1) expression contributed to cisplatin resistance and tumour progression in non-small-cell lung cancer cells by downregulating miR-524-5p, which promoted the expression of methyltransferase 3 N6-adenosine-methyltransferase complex catalytic subunit and SOX2 [139]. This evidence concerns the gene SOX2 and non-small cell lung carcinoma.