After an NP-hydrogel system administration, TUNEL assay showed a drastic increase in apoptotic rate in a colon cancer cell line, while immunofluorescence for CD31 with FITC-conjugated probes showed a markedly reduced angiogenesis in tumor samples from mice bearing colorectal peritoneal carcinomatosis [107]. Here, PECAM1 is linked to malignant colon neoplasm.