This finding was corroborated by immunofluorescence with antibodies conjugated with Alexa Fluor® 568 or Alexa Fluor® 594 for γH2AX (a phosphorylated form of H2A histone family member X used as a marker of DNA double-strand DNA breaking and repair), hypoxia-inducible factor 1-α, carbonic anhydrase IX (a diagnostic marker for various cancers), and caspase-3. The gene discussed is CASP3; the disease is cancer.