COMT and Parkinson disease: Other medications used to treat PD are DA receptor agonists (pramipexole, ropinirole, rotigotine, piribedil), amantadine (NMDA receptor antagonist), monoamine oxidase B (MAO B) and catechol-O-methyltransferase (COMT) inhibitors (selegiline, rasagiline, safinamide and entacapone, tolcapone, opicapone), and anticholinergics (biperiden, pridinol).