Proteins with higher cancer abundance in this dataset that have previously been implicated in prostate cancer progression but not yet as blood markers include the coatamer protein COPG2 [52], oncogenic signaling protein BTK [53], and plasminogen activator PLAT, a known downstream gene target of ERG in tissues positive for the TMPRSS2–ERG fusion [54]. This evidence concerns the gene TMPRSS2 and Familial prostate cancer.