Conversely, the review by Karimi et al. [27] acknowledged the effectiveness of various systemic inflammation markers like NLR, SII, and CRP ratios in assessing COVID-19 prognosis but pointed out that despite the promising results, NLR remains the most validated marker due to extensive studies confirming its prognostic value, although other markers including SII showed potential in certain studies. This evidence concerns the gene CRP and COVID-19.