In particular, the ratio RANKL/OPG displayed a very significantly higher level in OM-positive patients compared to negative ones, as confirmed by a very good value of ROC AUC (AUC = 0.938, Figure 3f), though there was a quite high standard deviation in OM patients due to the high standard deviation of RANKL. The gene discussed is TNFSF11; the disease is ocular melanoma.