Consistent with their diagnostic accuracy, the strongest positive correlation with sCD14 ST was observed for the RANKL/OPG ratio, SuPAR, Sclerostin, and CCL2, while a significant negative correlation was observed for those biomarkers with bone-protective roles, such as OPG, or anti-inflammatory functions, such as IL-10, which were higher in OM-negative patients. Here, SOST is linked to ocular melanoma.