So far, Broyde et al. [40] evaluated the Ki-67 PI in 319 newly diagnosed cases of NH nBCLs in histological sections and showed a statistically significant increase in the mean Ki-67 PI values from 26.6% for indolent lymphomas to 67.2% for aggressive lymphomas and to 97.6% for very aggressive lymphomas. The gene discussed is MKI67; the disease is lymphoma.