In the CC/CIN-associated TME, N1-type neutrophils, M1-type macrophages, NK cells, DCs, and CD4+ and CD8+ T lymphocytes secrete cytokines, such as IL-2, IL-12, IL-18, and interferon-γ (IFNγ), as part of their combat against pre-malignant and malignant cells. This evidence concerns the gene IL18 and cervical squamous intraepithelial neoplasia.