There were also significant (p < 0.05) but rather weak correlations between BMI z-score and fasting insulin (r = 0.15), HOMA-IR (r = 0.18), HDL (r = −0.13), HDL (r = −0.18), and uric acid (r = 0.17), to some extent confirming the relationships between the degree of obesity and metabolic disorders. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.