Some similarities of patients with IH at 1h-PG to ones with prediabetes and differences with respect to ones with NGT may reflect the earliest disorders of insulin secretion and/or sensitivity; however, confirming this hypothesis requires continuation of research, including follow-up of the patients with NGT according to the criteria of ADA [8] and IH at 1h-PG according to IDF [13]. The gene discussed is INS; the disease is isolated hemihyperplasia.