Furthermore, a previous study has shown that WD-driven gut dysbiosis dysregulated bile acid synthesis by lowering the gene expression of the enzymes involved in the synthesis, which eventually compromised TGR5 signaling in the brain and microglia, resulting in systemic inflammation, microglial activation, and reduced neuroplasticity with ultimate cognitive impairment [172]. The gene discussed is GPBAR1; the disease is Cognitive impairment.