Interestingly, Ets transcription factors ER81 and Elk1 were found to bind to the proximal promoter elements of the human PSEN1 gene and activate PSEN1 transcription, which in turn, according to the amyloid hypothesis, leads to the increased production of Aβ42 and deposition of amyloid plaques in the brains of FAD [203,204]. Here, PSEN1 is linked to amyloidosis.