E2F1 and Alzheimer disease: Moreover, a transcription factor (TF) interaction analysis and DEG-microRNAs (miRNAs) interaction analysis revealed that the transcriptional regulators for the differentially expressed genes common in tissues of patients with T2D and neurological diseases are FOXC1, GATA2, FOXL1, YY1, E2F1, NFIC, NFYA, USF2, HINFP, MEF2A, SRF, NFKB1, USF2, HINFP, MEF2A, PDE4D, CREB1, SP1, HOXA5, SREBF1, TFAP2A, STAT3, POU2F2, TP53, PPARγ, and JUN, suggesting a link between T2D and AD [192].