PDE4D and type 2 diabetes mellitus: Moreover, a transcription factor (TF) interaction analysis and DEG-microRNAs (miRNAs) interaction analysis revealed that the transcriptional regulators for the differentially expressed genes common in tissues of patients with T2D and neurological diseases are FOXC1, GATA2, FOXL1, YY1, E2F1, NFIC, NFYA, USF2, HINFP, MEF2A, SRF, NFKB1, USF2, HINFP, MEF2A, PDE4D, CREB1, SP1, HOXA5, SREBF1, TFAP2A, STAT3, POU2F2, TP53, PPARγ, and JUN, suggesting a link between T2D and AD [192].