Of course, we are aware that CYP24A1 and SLC34A1 mutations, hypercalciuria, hypercalcemia, nephrolithiasis, nephrocalcinosis and a history of other types of vitamin D hypersensitivity in an individual or family members should always be excluded before starting high-dose treatments such as those we have indicated for consideration by medical doctors. The gene discussed is CYP24A1; the disease is nephrolithiasis.