In addition, the volunteers with obesity showed higher ratios between IL-1β and IL-10 (A, p < 0.0001), IP-10 and IL-10 (D, p < 0.05), TNF-α and IL-10 (E, p < 0.0001), IL-12p70 and IL-10 (F, p < 0.01), IFN-γ and IL-10 (G, p < 0.05), and GM-CSF and IL-10 (H, p < 0.0001) than the NW group. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.