IL10 and obesity due to melanocortin 4 receptor deficiency: In the present study, it was reported for the first time that the regulated systemic inflammatory status observed in older people with an adequate weight, especially due to IL-10, had a significant impact on CMI, whilst the imbalance of this systemic inflammatory status towards a pronounced pro-inflammatory state profile, observed in the older people with obesity, led to the loss of any impact of this status on CMI.