6-MSITC also mediated apoptotic effects through the PI3K/AKT pathway (see Section 5.6), causing a reduction in phosphorylated AKT and inhibiting NF-κB in MCF-7, MDA-MB-231, MDA-MB- 435S, and Hs578T human breast cancer cell lines [30]. The gene discussed is NFKB1; the disease is breast cancer.