The neuroprotective effects of 6-MSITC through the activation of the transcription factor Nrf2 (NF-E2-related factor 2) were investigated using the AppNL-G-F/NL-G-F knock-in (AppNLGF) mouse model of Alzheimer’s disease (AD). This evidence concerns the gene NFE2L2 and early-onset autosomal dominant Alzheimer disease.