Chronic inflammatory status is known to activate Wnt/β-catenin signaling in the intestine, which is a pivotal tumorigenic pathway involved in over 90% of CRC cases, via pro-inflammatory mediators such as TNF-α [40], IL-6 [41], PGE2 [42], and CCL2 [43]. The gene discussed is TNF; the disease is colorectal carcinoma.