Interestingly, kaempferol has also been reported to cause induction of apoptosis, as demonstrated by the increased expression of Bax and decreased expression of Cathepsin D (an essential lysosomal aspartic protease involved in breast cancer metastasis) in triclosan and estradiol-treated MCF-7 cells and a xenograft mouse model [80]. The gene discussed is BAX; the disease is breast cancer.