CASP3 and breast cancer: Interestingly, the treatment of ex vivo neo-adjuvant chemotherapy-treated primary human breast cancer tissues with kaempferol showed a notable downregulation of p53, ki-67, NANOG, NF-κB, CD 44, ALDH1, Bcl2, and upregulation in the expression of caspase 3 in comparison to the treatment with carboplatin, which indicates the ability of kaempferol to reverse the acquired chemo-tolerance in advanced stage breast cancer tumors [71].