CD8A and neoplasm: Within the TME, the immune cells, helper CD4 + T cells (Th1), and cytotoxic CD8 cells by their cytokine IFN-γ, produce significant antitumor effects, and conversely, the myeloid-derived suppressive cells (MDSC) and tumor-associated macrophages (TAM) along with their associated cytokines IL-1beta, IL-6, and TNF-alpha become involved in tumor progression [114].