IL2 and neoplasm: Jiang et al. reported that cGAMP-mediated STING/STAT3 can inhibit the activity, proliferation and invasion of tumor cells and inhibit tumor progression through upregulating IL-2, TNF-α and IFN-γ by cGAMP and downregulating CXCL8, BCL-2 and VEGFA to inhibit angiogenesis [53].