Confirming this fact, the pathological accumulation of LPA occurs in the liver and adipose tissue of rats upon the knockdown of Agpat2 (Lplat2 in the novel nomenclature [139,140]), thus affording an experimental model of the most common congenital lipodystrophy caused by inactivating mutations of the AGPAT2 gene (see Figure 2) [33]. The gene discussed is AGPAT2; the disease is lipodystrophy.