ENPP7 and cancer: As reviewed by Duan [503], three mechanisms might be involved in the increased susceptibility of ENPP7-KO mice to cancer and inflammation as follows: decreases in apoptotic ceramide accumulation, increases in proinflammatory PAF, another substrate of ENPP7 [269], and a lack of LPC degradation into monoacylglycerol [268], leading to the stimulated production of LPA by ATX.