Still, more obvious coupling between LIPH and LPA6 was found in hair follicles, where homozygous mutations of either LIPH or LPA6 result in a congenital hair deficiency called wooly hair/sparse hair or hypotrichosis (see [204] for a very elegant description of the pathophysiological mechanisms underlying that hair disorder and for references to discovered human mutations). This evidence concerns the gene LPAR6 and disorder of pilosebaceous unit.