ACHE and Alzheimer disease: Scopoletin (3) is a simple, naturally occurring coumarin, endowed with many interesting properties for combatting AD: it is an inhibitor of AChE and a neuroprotective compound, able to reduce neurodegeneration via the activation of anti-oxidant enzymes [36], and showed promising anti-oxidant potential by protecting neuronal living cells against Aβ 25–35-induced cytotoxicity [37].