Aiming at counteracting the oxidative stress implicated in AD pathogenesis, Lee et al. reported the design of a series of derivatives obtained by merging the coumarin core, acting as a free radical scavenger, and the chalcone structure of Licochalcone A. Among the obtained compounds, LM-031 (Figure 14) showed the ability to upregulate CREB, demonstrating promising neuroprotective activity and the potential to reduce oxidative stress, as well as Aβ and tau accumulation [17]. The gene discussed is MAPT; the disease is Alzheimer disease.