Indeed, the coumarin nucleus showed the ability to affect various pathways and targets involved in the pathology, including the abovementioned AChE and BChE, BACE-1 and COX-2, but also lipoxygenase (LOX), cannabinoid receptors (CBRs) and fatty acid amide hydrolase enzyme (FAAH), GABA receptors and monoaminoxidases (MAOs), which are similarly considered to be involved in the AD pathogenic mechanisms [16,17]. This evidence concerns the gene ACHE and Alzheimer disease.