The use of the inhibitors SB02024 or SAR405 to inhibit VPS34 kinase activity led to increased levels of CCL5, CXCL10, and IFN-γ in the tumor microenvironment (TME), resulting in increased levels of tumor infiltration by NK cells and T cells in melanoma and colorectal cancer models [84]. The gene discussed is CCL5; the disease is neoplasm.