The above data suggested that AGAP2-AS1 promoted cell growth, migration, invasion and EMT process of CRC via regulating E2F4/miR-182-5p/CFL1, miR-497/FGFR1, hsa-miR-15/16, Ras/MAPK and miR-4668-3p/SRSF1 pathways. The gene discussed is AGAP2; the disease is colorectal carcinoma.