The practical aspect of our observations is that the decision to choose a cART regimen may be based on the examination of certain new parameters, such as SIRT-6, IRS, MSTN, GLP-1, FETU-A, PTX3, and RANTES, for which the outcomes may predict the development of metabolic disorders after years of use of particular cART regimens. This evidence concerns the gene SIRT6 and Other metabolic disease.