Accordingly, APS was defined when at least one clinical criterion (thrombotic event and/or obstetric morbidity) and at least one laboratory criterion (persistently positive lupus anticoagulant (LA) and/or persistently positive anticardiolipin and/or anti-beta2 glycoprotein I IgG/IgM) were present. Here, CD40LG is linked to autoimmune polyendocrinopathy.