VEGFA and wet macular degeneration: Similar to the treatment of neovascular age-related macular degeneration (nAMD), the first-line treatment for DME usually involves intravitreal injections of anti-vascular-endothelial-growth-factor (VEGF) drugs such as Bevacizumab, Aflibercept, Ranibizumab or Brolucizumab.