In a retrospective study on patients who had undergone major colorectal surgery for colorectal cancer, McSorely et al. [11] reported that perioperative blood transfusions were associated with an increased systemic postoperative inflammatory response (measured with c-reactive protein), postoperative complications (p = 0.0197), anastomotic dehiscence (p = 0.021), and hospital stay (p = 0.011), without any change in the rate of long-term survival (overall survival or cancer-specific survival) in the compared groups. The gene discussed is CRP; the disease is cancer.