et al. analyzed the role of macrophages in obesity islet inflammation explaining that islet-resident macrophages underlie the inflammatory response in obesity and mechanistically participate in the β-cell hyperplasia and dysfunction that characterizes this insulin-resistant state; also, they found that during chronic inflammation, circulating monocytes infiltrate and accumulate in inflamed tissue sites [26]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.