Therefore, if confirmed, nuclear translocation of KLHL14 with E-cadherin could represent a novel biomarker of tumor EMT as well as a potential therapeutic target to block adenoma invasion of suprasellar and parasellar structures, which represents one of the most important characteristics that increases the surgical degree of difficulty and often results in an incomplete extent of resection, therefore leading to an increased frequency of recurrent disease [48,49]. Here, KLHL14 is linked to neoplasm.