Initially, BISAP ≥ 2, SIRS on admission, SIRS after 48 h, lactate ≥ 2.05 mEq/L, procalcitonin ≥ 0.32 ng/dL, glucose ≥ 130 mg/dL, creatinine ≥ 1.3 mg/dL, BUN ≥ 28 mg/dL, neutrophils ≥ 84.7%, neutrophils after 48 h ≥ 83.4%, leucocytes after 48 h ≥ 12.735 × 109/L, BUN after 48 h ≥ 30 mg/dL, CRP after 48 h ≥ 280 mg/dL, rising BUN, heart rate increased over 20 bpm with respect to previous value, were included in the logistic regression. This evidence concerns the gene CRP and systemic inflammatory response syndrome.