A study using a mouse model of lupus with a genetic defect that blocks IL-17 production by Amarilyo et al. showed that ANA was not present in circulation in animals, and anti-dsDNA, anti-single-stranded DNA (anti-ssDNA), anti-ribonucleoprotein (RNP) and anti-chromatin antibodies were also not present [94]. The gene discussed is IL17A; the disease is systemic lupus erythematosus.