KDR and central nervous system cancer: Our pooled analysis of six studies (n = 4828) showed that the recessive model of KDR/VEGFR2 (rs2071559) gene polymorphism (CC vs. CT + TT) was associated with a higher risk of developing gliomas [OR 1.52 (95% CI 1.25–1.85), p < 0.001, I2 = 24%, random-effects models] (Figure 2B).