KDR and central nervous system cancer: Our pooled analysis of six studies (n = 4828) showed that the dominant model of KDR/VEGFR2 (rs2071559) gene polymorphism (CC + CT vs. TT) was associated with a higher risk of developing gliomas [OR 1.40 (95% CI 1.24–1.57), p < 0.001, I2 = 0%, random-effects models] (Figure 2A).