Our meta-analysis from a total of six studies (n = 4156) showed that the genetic model consisting of CT genotypes of KDR/VEGFR2 (rs2071559) gene polymorphism was associated with a higher risk of gliomas than the model consisting of TT genotypes [OR 1.30 (95% CI 1.15–1.47), p < 0.001, I2 = 0%, random-effects models] (Figure 3B). Here, KDR is linked to central nervous system cancer.