In detail, an unPAD diagnosis was made in 55/110 (50%), whereas 18/110 (16%), 6/110 (5%), 3/110 (3%), and 1/110 (1%) patients developed a selective IgM deficiency, CVID, selective IgA deficiency, and IgG3 subclass deficiency, respectively. This evidence concerns the gene IGHG3 and Decreased circulating total IgM.