However, GH secretion stimulation tests are not necessary in children and adolescents when there are clinical, auxological, and hormonal criteria (e.g., low serum IGF-1 and IGF-BP3 levels) that are compatible with GHD; in cases of hypothalamic-pituitary tumors treated with surgery and/or radiotherapy; and in patients with a combined deficiency of at least one other adenohypophyseal hormone secondary to surgery [71]. The gene discussed is IGFBP3; the disease is pituitary tumor.