Both ACTH and cortisol concentrations were significantly decreased between 2 h and 96 h post-TA treatment; the visible decrease in both ACTH and cortisol at 32 h was not considered a significant treatment effect due to the concomitant decrease in the control and APS groups, which is likely attributable to diurnal variations that are typically observed. Here, POMC is linked to autoimmune polyendocrinopathy.