In future studies, greater attention should be paid to scientific questions such as whether LOPs are involved in influencing the role of tight-junction proteins (ZO-1, occludin) of colonic tissues in the intestinal barrier, the predominant bacterial genera involved in the prevention of colitis, and the ways in which they are involved in the immune process and inflammatory signalling pathways (NF-κB, MAPK) in a scientific manner. The gene discussed is NFKB1; the disease is colitis.