Hyperlipidemia often coexists with other metabolic diseases due to abnormal lipid metabolism, such as abnormal glucose metabolism [20], obesity [21], etc. In this study, the FBG concentration in the MG group induced by a high-fat diet was 7.61 ± 0.76, which was significantly increased compared to that of the NC group (p < 0.01), and the detailed results are shown in Table S2 and Figure 2A. Before the intervention, the FBG concentrations of AG, SH-L, SH-M, and SH-H were 7.44 ± 0.86, 7.24 ± 0.46, 7.60 ± 0.94, and 7.18 ± 0.80, respectively; these were not significantly different from that of MG. Here, RENBP is linked to obesity due to melanocortin 4 receptor deficiency.